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*MRI Basics*
MRI machines make use of the fact that body tissue contains lots of water, and hence protons (1H nuclei), which get aligned in a large magnetic field.\[4\] Each water molecule has two hydrogen nuclei or protons. When a person is inside the powerful magnetic field of the scanner, the average magnetic moment of many protons becomes aligned with the direction of the field. A radio frequency current is briefly turned on, producing a varying electromagnetic field. This electromagnetic field has just the right frequency, known as the resonance frequency, to be absorbed and flip the spin of the protons in the magnetic field. After the electromagnetic field is turned off, the spins of the protons return to thermodynamic equilibrium and the bulk magnetization becomes re-aligned with the static magnetic field. During this relaxation, a radio frequency signal (electromagnetic radiation in the RF range) is generated, which can be measured with receiver coils.
Magnetic resonance spectroscopy (MRS) is used to measure the levels of different metabolites in body tissues. The MR signal produces a spectrum of resonances that correspond to different molecular arrangements of the isotope being "excited". This signature is used to diagnose certain metabolic disorders, especially those affecting the brain,\[48\] and to provide information on tumor metabolism.\[49\]
Magnetic resonance spectroscopic imaging (MRSI) combines both spectroscopic and imaging methods to produce spatially localized spectra from within the sample or patient. The spatial resolution is much lower (limited by the available SNR), but the spectra in each voxel contains information about many metabolites. Because the available signal is used to encode spatial and spectral information, MRSI requires high SNR achievable only at higher field strengths (3 T and above).
*Magnetic Resonance Imaging*
Proton nuclear magnetic resonance (NMR) detects the presence of hydrogens (protons) by subjecting them to a large magnetic field to partially polarize the nuclear spins, then exciting the spins with properly tuned radio frequency (RF) radiation, and then detecting weak radio frequency radiation from them as they "relax" from this magnetic interaction. The frequency of this proton "signal" is proportional to the magnetic field to which they are subjected during this relaxation process. In the medical application known as Magnetic Resonance Imaging (MRI), an image of a cross-section of tissue can be made by producing a well-calibrated magnetic field gradient across the tissue so that a certain value of magnetic field can be associated with a given location in the tissue. Since the proton signal frequency is proportional to that magnetic field, a given proton signal frequency can be assigned to a location in the tissue. This provides the information to map the tissue in terms of the protons present there. Since the proton density varies with the type of tissue, a certain amount of contrast is achieved to image the organs and other tissue variations in the subject tissue.
\* Since the MRI uses proton NMR, it images the concentration of protons. Many of those protons are the protons in water, so MRI is particularly well suited for the imaging of soft tissue, like the brain, eyes, and other soft tissue structures in the head as shown at left. The bone of the skull doesn't have many protons, so it shows up dark. Also the sinus cavities image as a dark region.
Bushong's assessment is that about 80% of the body's atoms are hydrogen atoms, so most parts of the body have an abundance of sources for the hydrogen NMR signals which make up the magnetic resonance image.
The schematic below may help visualize the imaging process. It is presumed that there are two regions of the sample which contain enough hydrogens to produce a strong NMR signal. The top sketch visualizes an NMR process with a constant magnetic field applied to the entire sample. The hydrogen spin-flip frequency is then the same for all parts of the sample. Once excited by the RF signal, the hydrogens will tend to return to their lower state in a process called "relaxation" and will re-emit RF radiation at their Larmor frequency. This signal is detected as a function of time, and then is converted to signal strength as a function of frequency by means of aFourier transformation. Since the protons in each of the active areas of the sample are subjected to the same magnetic field, they will produce the same frequency of radiation and the Fourier transform of the detected signal will have only one peak. This one peak demonstrates the presence of hydrogen atoms, but gives no information to locate them in the sample.
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Information about the location of the hydrogen atoms can be obtained by adding a calibrated gradient field across the region of the sample as shown in the bottom sketch above. With an increasing magnetic field as you move to the right across the sample, the spin-flip energy and therefore the frequency of the emitted signal increases from left to right. When excited by an RF transmitter, the emitted signal contains different frequencies for the two proton concentration areas. These frequencies can be separated by means of the Fourier transform and the example gives two different regions of frequency for the two sample areas. This is the beginning of the process of locating the hydrogen atoms. In the sketch, it only locates them along the horizontal direction, giving no indication that they are at different heights.